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Publications

• Bolger N, Heffron C, Regan I, Sweeney M, Kinsella S, McKeown M, Creighton G, Russell J, O'Leary J. Implementation and evaluation of a new automated interactive image analysis system. Acta Cytol. 2006 Sept-Oct; 50(5):481-2. PMID: 17017432
• Martin CM, Spillane C, Kehoe L, O'Leary JJ. Gene Discovery in Cervical Cancer: towards diagnostic and therapeutic biomarkers. Mol Diagn and Ther, 2007; 11(5):277-90. PMID: 17963416.
• Martin CM, Astbury K, O'Leary JJ. Molecular Profiling of Cervical Neoplasia. Expert Reviews in Molecular Diagnostics, 2006; 6(2), 217-229.
• Astbury K, Martin CM, Ring M, Pilkington L, Bolger N, Sheils O, O'Leary JJ. Future Molecular Aspects of Cervical Cytology. Current Diagnostic Pathology, 2006; 12, 104-113.
• Martin CM, Astbury, K, O'Leary JJ. Identification of Cell Cycle Regulatory Molecules as Biomarkers in Cervical Cancer by Gene Expression Profiling, and Validation by Immunohistochemistry and RT PCR. Methods in Molecular Medicine. Edited by Humana Press. In press.
• Martin CM. O'Leary JJ. Cerviva The Irish Cervical screening research consortium. DMMC Newletter. August 2007. (pdf download)
• Martin CM, O'Leary JJ. Working towards a world class cervical screening program for Irish women. Cancerwise, 2007, 6(2) 17-21. (pdf download)
• O'Leary JJ. Working towards a world class cervical screening program for Irish women. Cancer Professional, 2007
• Keegan H, Mc Inerney J, Pilkington L, Grønn P, Silva I, Karlsen F, Bolger N, Logan C, Furuberg L, O'Leary JJ, Martin CM. Comparison of HPV detection technologies; Hybrid capture 2, PreTect? HPV-Proofer and analysis of HPV DNA viral load in HPV16, HPV18 and HPV33 E6/E7 mRNA positive specimens. J. Virol. Methods, 2008. In press.
• Astbury K, McEvoy L, Ring M, Pilkington L, Kehoe L, Spillane C, Sheils OM, Martin CM, O'Leary JJ. Potential biomarkers of cervical cancer identified by gene expression profiling and TaqMan polymerase chain reaction. Molecular Cancer. Submitted
• Martin CM, Sheils O, O'Leary JJ. MicroRNA signatures in cervical cancer - hierachical control of gene expression. Expert Opinion on Biological Therapy. In press
• Astbury K, Martin CM, Ring M, O'Leary JJ. Molecular Markers in Human Papilloma Virus-induced Female Genital Tract Cancers. Disease Markers. In press.

Presentations

• O'Leary JJ. Cancer, Genes, Proteins and Stemness. Professorial Inaugural Lecture as Chair of Pathology at TCD, 17th May, 2007.
• Keegan H, Mc Inerney J, Pilkington L, Grønn P, Silva I, Karlsen F, Bolger N, O'Leary JJ, Martin CM. Evaluation of HPV DNA and mRNA Detection Technologies for Detecting HPV in Cervical Cytology Specimens. Oral presentation at Pathological Society of Great Britain and Ireland, Winter Meeting, Oxford 7-9th January 2008. (Project 8)
• Keegan H, Mc Inerney J, Pilkington L, Grønn P, Silva I, Karlsen F, Bolger N, O'Leary JJ, Martin CM. Comparison of HPV Detection technologies; Hybrid Capture II (Digene), Pretect HPV Proofer (Norchip) and Real time PCR for Detection of HPV in cervical cytology specimens. Oral Presentation at Eurogin, New Strategies in Cervical Cancer Prevention, Monte Carlo, Monaco, 4-6th Oct, 2007. (Project 8)
• Martin, CM. HPV DNA and mRNA testing in the Irish Cervical Screening Population. Presentation at Norchip Satellite Symposium meeting, Eurogin, New Strategies in Cervical Cancer Prevention, Monte Carlo, Monaco, 4-6th Oct, 2007. (Project 5)
• O'Shea D Doolan C, Bolger N, Cullen R, Pilkington L, Martin C, Magee D, Griffin M, Gibbons D, O'Leary JJ. Development of a virtual web based external quality assessment (EQA) scheme in Cytopathology. Modern Pathology May 2008; 21 [Supplement 2s]: S1-S55. (Project 2)
• O'Shea D Doolan C, Bolger N, Cullen R, Pilkington L, Martin C, Magee D, Griffin M, Gibbons D, O'Leary JJ. Development of a virtual web based external quality assessment (EQA) scheme in Cytopathology. Laboratory Investigation, Jan 2008; 88 [Supplement 1f]: 4a - 396a. (Project 2)
• Ni Cheallaigh C, Sheils O, Griffiths S, Webster P, Martin C, McInerney J, Keegan H, O'Leary J, Lyons F, Bergin C, Mulcahy F, Clarke S. Oncogenic HPV sustypes in HIV-positive women. The 18th European Congress of Clinical Microbiology and Infectious Diseases (Barcelona, 19th -22nd April 2008) (Project 6)
• Murphy J, Sharp L, Carsin AE. Attitudes of GPs towards HPV vaccination: results from a national survey in Ireland. UK National Cancer Research Institute Cancer Conference, Birmingham, 2nd October 2007. (Project 3)
• Murphy J, Sharp L, Carsin AE. GPs' views on screening for cervical cancer and HPV testing: results from a national survey in Ireland. United Kingdom Association of Cancer Registries Annual Conference 2007, Birmingham, 31st October 2007. (Project 3)
• Kehoe L, Ring M, Pilkington L, Keegan H, Astbury K, Sheils O, Griffin M, Gaffney E, Gibbons D, Martin CM, O'Leary JJ. Villoglandular Adenocarcinoma of the cervix: High Risk HPV infection is associated with disruption of DNA licensing and replisome proteins. Poster at Pathological Society of Great Britain and Ireland, Winter Meeting, Oxford 7-9th January 2008. (Project 8)
• Keegan H, Mc Inerney J, Pilkington L, Grønn P, Silva I, Karlsen F, Bolger N, O'Leary JJ, Martin CM. Evaluation of HPV DNA and mRNA Detection Technologies for Detecting HPV in Cervical Cytology Specimens. Poster presentation at 24th International Papillomavirus Conference and Clinical Workshop in Beijing, China, from November 3rd-9th 2007. (Project 8)
• Martin C, Astbury K, Becker C, Henfrey R, Sherlock J, Guenther S, Sheils O, O'Leary JJ. MicroRNA signatures in Cervical Cancer: suggests hierarchical miRNA control of gene expression. Laboratory Investigation, 2007 (87) Supplement 1, 207A. (Project 8)
• O'Toole SA, Laios A, Sheppard B, Gleeson N, D'Arcy T, McGuinness E, Ring M, Gaffney E, Flavin R, Martin C, O'Brien J, O'Connell D, Sheils O, Cahill D, O'Leary JJ. miRNA Signatures in Primary versus Recurrent Ovarian Cancers. Laboratory Investigation, 2007 (87) Supplement 1, 209A. (Project 8)
• Ring M, Crowther S, Martin C, Astbury K, Sheils O, Griffin M, Gaffney E, Gibbons D, O'Leary JJ. Significant dysregulation of DNA replication license and replisome proteins in villoglandular carcinomas of the cervix indicates possible aggressive biological behaviour. Laboratory Investigation, 2007 (87) Supplement 1, 970A. (Project 8)
• Martin CM, Astbury K, Henfrey R, Sheils O, Gallagher M, Heffron C, Logan C, O'Leary JJ. miRNA Expression Signatures in Cervical Cancer. Modern Pathology; 2006 (19): Supplement 1, 171A. (Project 8)
• Astbury K, Martin CM, Smyth P, O'Leary JJ. Identification of Cell Cycle Regulatory Molecules as Biomarkers in Cervical Cancer using Gene Expression Profiling. Modern Pathology; 2006 (19): Supplement 1, 171A. (Project 8)
• Martin CM, Astbury K, Henfrey R, Sheils O, Gallagher M, Heffron C, Logan C, O'Leary JJ. miRNA Expression Signatures in Cervical Cancer. Laboratory Investigations, 2006 (86): 189A. (Project 8)
• Astbury K, Martin CM, Smyth P, O'Leary JJ. Identification of Cell Cycle Regulatory Molecules as Biomarkers in Cervical Cancer using Gene Expression Profiling. Laboratory Investigations, 2006 (86): 171A. (Project 8)
• Murphy J, Sharp L, Martin C, Pilkington L, Sheils O, O'Leary J, on behalf of the Irish Cervical Screening Research Consortium (CERVIVA). Women's knowledge and attitudes regarding cervical screening and human papillomavirus (HPV): Focus group findings from Ireland. Oral presentation at British Society for Clinical Cytology, 47th Annual Scientific Meeting, Dublin, Sept 2008. (Project 3)
• Murphy J, Sharp L, Carsin AE HPV infection, testing and vaccination: knowledge, attitudes and practices among GPs. Poster presentation at British Society for Colposcopy and Cervical Pathology conference 2008. (Birmingham10/11 April 2008) (Project 3)
• Murphy J, Sharp L, Carsin AE GPs' knowledge of HPV infection and vaccination: Is there a need for further professional education. Poster presentation at NHS confederation conference, Delivering better health services. (Manchester 4/5 June 2008). (Project 3)
• Murphy J, Sharp L, Martin C, Pilkington L, Sheils O, O'Leary J, on behalf of the Irish Cervical Screening Research Consortium (CERVIVA) Irish women's attitudes & knowledge of cervical screening & human papillomavirus (HPV): Preliminary findings from a focus group study. Poster presentation at UCC/Cork University Teaching Hospitals Health Research Day, 6 June 2008. (Project 3)
• Spillane CD, Kehoe L, Sheils O, Martin CM, O'Leary JJ. Silencing of HPV viral oncogenes E6 and E7 in cervical cancer. EUROGIN 2008 JOINING FORCES FOR CERVICAL CANCER PREVENTION NICE, France, November 12-15, 2008. (Project 8)
• Mc Inerney J, Pilkington L, Keegan H, Ring M, Bolger N, Casey M, Sheils O, O'Leary JJ, Martin CM. Prevalence and genotype distribution of Human Papilloma Virus in the Irish Cervical Screening Population. EUROGIN 2008 JOINING FORCES FOR CERVICAL CANCER PREVENTION NICE, France, November 12-15, 2008. (Project 5)
• Kehoe L, Spillane CD, Martin C, O'Leary JJ. Elucidation of the role of the p16INK4A pathway in the cell cycle and its relationship with the Human Papilloma Virus in cervical cancer. EUROGIN 2008 JOINING FORCES FOR CERVICAL CANCER PREVENTION NICE, France, November 12-15, 2008. (Project 8)
• Martin CM, Mc Inerney J, Keegan H, Pilkington, L, Ni Cheallaigh C, Delamere S, Griffin M, McHugh G, Webster P, Barrett M, Lyons F, Bergin C, Mulcahy F, Clarke S, Sheils O, O'Leary JJ. Human Papillomavirus prevalence and persistence, in the cervix of women with human immunodeficiency virus. EUROGIN 2008 JOINING FORCES FOR CERVICAL CANCER PREVENTION NICE, France, November 12-15, 2008. (Project 6)
• Normand C. A Comparison of the Thin Prep Imaging System and Manual Screening by Meta Analysis and Systematic Review. The British Society for Colposcopy and Cervical Pathology (BSCC) Annual Meeting, oral presentation, Dublin 2008. (Project 1)
• McInerney J, Pilkington L, Keegan H, Ring M, Bolger N, Sheils O, O'Leary J, Martin CM. Human Pappiloma Virus prevalence and genotype distribution in the Irish cervical screening population. The British Society for Colposcopy and Cervical Pathology (BSCC) Annual Meeting, oral presentation, Dublin 2008. (Project 5)
• Keegan H, McInerney J, Pilkington L, Grønn P, Silva I, Karlsen F, Bolger N, Logan C, Furuberg L and O'Leary JJ. Comparison of PRETECT HPV-proofer and hybrid capture II for HPV detection with viral load analysis of HPV 16, HPV 18 and HPV 33 E6/E7 mRNA positive specimens. The British Society for Colposcopy and Cervical Pathology (BSCC) Annual Meeting, oral presentation, Dublin 2008. (Project 8)
• O'Leary JJ. p16 and Replisome Associated Proteins in Cervical Pre-Cancer and Cancer. The British Society for Colposcopy and Cervical Pathology (BSCC) Annual Meeting, oral presentation, Dublin 2008. (Project 8)
• Hagmar B. Integration of Biomarkers in Cervical Cytology. The British Society for Colposcopy and Cervical Pathology (BSCC) Annual Meeting, oral presentation, Dublin 2008. (Project 8)
• Murphy J, Sharp L, Carsin AE Attitudes and knowledge of GPs towards HPV infection, testing and vaccination: results from a national survey in Ireland. Society of Social Medicine Conference, UK, oral presentation, Sept. 2008. (Project 3)
• Murphy J, Sharp L, Martin C, Pilkington L, Sheils O, O'Leary J, on behalf of the Irish Cervical Screening Research Consortium (CERVIVA). Attitudes and knowledge of GPs towards HPV infection, testing and vaccination: results from a national survey in Ireland. National Cancer Research Institute, Birmingham, oral presentation, Oct. 2008 (Project 3)
• Murphy J, Sharp L, Martin C, Pilkington L, Sheils O, O'Leary J, on behalf of the Irish Cervical Screening Research Consortium (CERVIVA). A focus group study in Ireland of women's views, attitudes and knowledge of cervical screening and Human Papillomavirus (HPV). National Cancer Research Institute, Birmingham, poster presentation, Oct. 2008 (Project 3)
• Murphy J, Sharp L, Martin C, Pilkington L, Sheils O, O'Leary J, on behalf of the Irish Cervical Screening Research Consortium (CERVIVA). What are women's views on cervical screening and HPV vaccination? A qualitative study in Ireland EUROGIN conference 2008: Joining forces for cervical cancer prevention. Nice, France, oral presentation, Nov. 2008. (Project 3)
• Baier T, Hansen-Hagge T, Gransee R, Crombé A, Solli L, Gulliksen A, Martin C, Keegan H, O'Leary JJ, Riegger L, Mielnik M, Furuberg L. Towards automatic chip-based detection of HPV mRNA in cervical samples. For presentation at Lab 09, Hannover, Germany. (Project 8)
• Baier T, Furuberg L, Hansen-Hagge T, Gransee R, Crombé A, Solli L, Gulliksen A, Martin C, Keegan H, Riegger L, Mielnik M, O'Leary JJ, Karlsen F. Towards point of care chip based diagnostics based on mRNA. For presentation at Lab 09, Hannover, Germany. (Project 8)

Abstracts submitted

• L Kehoe, CM Spillane, C Martin, JJ O'Leary. p63 expression in Cervical Intraepithelial Neoplasia and Cervical Cancer.
• MG Barrett, C Hannigan, J McInerney, R Flavin, O Sheils, L Pilkington, CM Martin, M Grifffin, JJ O'Leary. Co-analysis of HPV DNA, mRNA E6/E7 HR-HPV expression and mcm2 and TopoIIa [ProEx C] in cervical pre-cancer.
• CD Spillane, L Kehoe, O Sheils, CM Martin and JJ O'Leary. Cervical Cancer - targeting of HPV Viral oncogenes / oncoproteins E6 and E7 by siRNA and molecular pharmacological approaches.
• M Gallagher, S Elabruhani, R Flavin, CM Martin, O Sheils, JJ O'Leary. Cervical Cancer - targeting of HPV Viral oncogenes / oncoproteins E6 and E7 by siRNA and molecular pharmacological approaches.